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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH18A1
All Species:
31.82
Human Site:
T430
Identified Species:
50
UniProt:
P54886
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54886
NP_001017423.1
795
87302
T430
L
K
R
L
S
L
S
T
S
K
L
N
S
L
A
Chimpanzee
Pan troglodytes
XP_001155890
796
87730
T431
L
K
R
L
S
L
S
T
S
K
L
N
S
L
A
Rhesus Macaque
Macaca mulatta
XP_001099359
795
87154
T430
L
K
R
L
S
L
S
T
S
K
L
N
S
L
A
Dog
Lupus familis
XP_534976
795
87233
T430
L
K
R
L
S
L
S
T
S
K
L
N
S
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z110
795
87278
T430
L
K
R
L
S
L
S
T
S
K
L
N
S
L
A
Rat
Rattus norvegicus
NP_001101994
795
87311
T430
L
K
R
L
S
L
S
T
S
K
L
N
S
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508419
607
66410
I272
R
V
V
R
R
T
L
I
A
K
N
L
E
L
E
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086040
815
89190
T450
L
K
R
L
S
L
S
T
A
K
L
N
S
L
A
Zebra Danio
Brachydanio rerio
NP_001077015
782
85358
S412
L
K
R
L
S
L
S
S
S
K
L
N
S
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649375
776
84074
P416
L
S
R
L
S
L
N
P
A
K
L
K
N
L
S
Honey Bee
Apis mellifera
XP_396399
732
79216
N390
I
A
N
D
S
L
T
N
V
G
R
V
L
R
R
Nematode Worm
Caenorhab. elegans
P54889
800
86509
P422
L
N
R
L
K
M
T
P
E
K
I
Q
D
L
H
Sea Urchin
Strong. purpuratus
XP_781524
752
81324
G390
K
L
K
S
L
S
D
G
L
R
Q
I
A
A
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54888
726
78853
Q391
G
R
V
L
K
K
T
Q
V
A
D
D
L
I
L
Baker's Yeast
Sacchar. cerevisiae
P54885
456
49722
I121
P
V
G
V
L
L
V
I
F
E
S
R
P
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.9
97.4
97.1
N.A.
95.3
95.2
N.A.
71.6
N.A.
84.4
82.1
N.A.
55.9
54.7
52.5
56.4
Protein Similarity:
100
94.9
98.2
98.6
N.A.
97.7
97.4
N.A.
74.9
N.A.
90.8
91.5
N.A.
70.8
69.5
69.5
73.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
13.3
N.A.
93.3
86.6
N.A.
53.3
13.3
33.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
N.A.
100
100
N.A.
80
26.6
53.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.1
38.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
20
7
0
0
7
7
47
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
7
0
0
0
7
7
7
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
7
7
0
0
7
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
7
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
0
0
0
0
0
0
14
0
0
7
7
0
7
0
% I
% Lys:
7
54
7
0
14
7
0
0
0
74
0
7
0
0
0
% K
% Leu:
67
7
0
74
14
74
7
0
7
0
60
7
14
74
7
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
0
0
0
7
7
0
0
7
54
7
0
0
% N
% Pro:
7
0
0
0
0
0
0
14
0
0
0
0
7
0
0
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
7
7
0
0
0
% Q
% Arg:
7
7
67
7
7
0
0
0
0
7
7
7
0
7
7
% R
% Ser:
0
7
0
7
67
7
54
7
47
0
7
0
54
0
14
% S
% Thr:
0
0
0
0
0
7
20
47
0
0
0
0
0
0
7
% T
% Val:
0
14
14
7
0
0
7
0
14
0
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _